Mu rwego rw'ubuvuzi bwa none, imiti yica udukoko yagaragaye ko ari imwe mu ntambwe zikomeye cyane, igabanya cyane umubare w'abandura n'impfu ziterwa n'udukoko twandura. Ubushobozi bwayo bwo guhindura ingaruka z'indwara za bagiteri bwatumye igihe cy'ubuzima cy'abarwayi benshi kiyongera. Imiti yica udukoko ni ingenzi mu buryo bugoye bwo kwa muganga, harimo kubagwa, gushyiramo imiti, gutera imiti, na chimiotherapie. Ariko, kugaragara kwa virusi zirwanya imiti yica udukoko byakomeje gutera impungenge, bigabanya ubushobozi bw'iyi miti uko igihe kigenda gihita. Ingero z'uko imiti yica udukoko yagaragaye mu byiciro byose bya antibiyotike uko imihindagurikire y'imiti ihinduka. Igitutu cy'imiti irwanya udukoko cyagize uruhare mu kwiyongera kw'imiti irwanya udukoko, bitera ikibazo gikomeye ku buzima bw'isi.
Kugira ngo harwanywe ikibazo gikomeye cyo kudakira imiti irwanya udukoko, ni ngombwa gushyira mu bikorwa politiki nziza zo kurwanya indwara zigabanya ikwirakwira ry’udukoko turwanya udukoko, hamwe no kugabanya ikoreshwa rya antibiyotike. Byongeye kandi, hakenewe cyane ubundi buryo bwo kuvura. Ubuvuzi bwa Oxygen Hyperbaric (HBOT) bwagaragaye nk'uburyo bwiza muri uru rwego, burimo guhumeka ogisijeni 100% ku gipimo runaka cy’umuvuduko mu gihe runaka. HBOT, ifatwa nk'uburyo bw'ibanze cyangwa bwuzuzanya ku ndwara zandura, ishobora gutanga icyizere gishya mu kuvura indwara zandura ziterwa n’udukoko turwanya antibiyotike.
Ubu buvuzi bukomeje gukoreshwa nk'uburyo bw'ibanze cyangwa ubundi buryo bwo kuvura indwara zitandukanye, harimo ububyimbirwe, uburozi bwa carbon monoxide, ibikomere bidakira, indwara zo mu bwonko, n'indwara zandura. Uburyo HBOT ikoreshwa mu kuvura indwara ni ingenzi cyane, butanga inyungu zikomeye ku barwayi.
Uburyo bwo kuvura ogisijeni ikabije mu buvuzi mu kwandura
Ibimenyetso bihari bishyigikira cyane ikoreshwa rya HBOT, haba mu kuvura ku giti cyayo ndetse no mu buryo bw’inyongera, bitanga inyungu zikomeye ku barwayi banduye. Mu gihe cya HBOT, umuvuduko wa ogisijeni mu maraso ushobora kuzamuka ukagera kuri 2000 mmHg, kandi umuvuduko mwinshi wa ogisijeni mu turemangingo ushobora kuzamura urugero rwa ogisijeni mu turemangingo ukagera kuri 500 mmHg. Ingaruka nk'izo ni ingenzi cyane mu gutuma habaho gukira kw'ingaruka z'ububyimbirwe n'imitsi itera amaraso mu buryo butunguranye bigaragara mu duce duto, ndetse no mu gucunga indwara zo mu bice by'umubiri.
HBOT ishobora kandi kugira ingaruka ku buzima bushingiye ku budahangarwa bw'umubiri. Ubushakashatsi bwerekana ko HBOT ishobora guhagarika indwara ziterwa na autoimmune syndromes ndetse n'ubwitange bw'umubiri buterwa na antigens, bigafasha mu gukomeza kwihanganira ikwirakwizwa ry'uturemangingo binyuze mu kugabanya urujya n'uruza rw'amaraso ya lymphocytes na leukocytes mu gihe ihindura uburyo ubudahangarwa bw'umubiri bwitwara. Byongeye kandi, HBOT ishobora no gukumira indwara ziterwa na autoimmune syndromes ndetse n'ubwitange bw'umubiri buterwa na antigens, bigafasha mu gukomeza kwihanganira ikwirakwizwa ry'uturemangingo binyuze mu kugabanya urujya n'uruza rw'amaraso ya lymphocytes na leukocytes mu gihe ihindura uburyo ubudahangarwa bw'umubiri bwitwara.bishyigikira gukiramu bisebe by’uruhu bidakira binyuze mu gushishikariza angiogenesis, inzira y’ingenzi yo kunoza gukira. Ubu buvuzi kandi butera inkunga ikorwa rya collagen matrix, icyiciro cy’ingenzi mu gukira kw’ibikomere.
Hagomba kwitabwaho cyane indwara zimwe na zimwe, cyane cyane indwara zikomeye kandi zigoye kuvura nka necrotizing fasciitis, osteomyelitis, indwara zidakira zoroshye, na endocarditis yandura. Imwe mu mikoreshereze ikunze gukoreshwa muri HBOT ni iyo kwandura indwara zoroshye mu ruhu na osteomyelitis ijyanye n'urugero ruto rwa ogisijeni ikunze guterwa na bagiteri zidakora neza cyangwa zidashobora kwihanganira.
1. Indwara z'ibirenge by'abarwaye diyabete
Ikirenge cy'abarwayi ba diyabeteIbisebe ni ikibazo gikunze kugaragara ku barwayi ba diyabete, kigira ingaruka ku bantu bagera kuri 25%. Ubwandu bukunze kugaragara muri ibi bisebe (bigizwe na 40%-80% by'abanduye) kandi bigatera ubwiyongere bw'uburwayi n'impfu. Ubwandu bwa diyabete ku birenge (DFIs) akenshi bugizwe n'ubwandu bwa mikorobe nyinshi hamwe n'ubwoko butandukanye bwa bagiteri zidafite umwuka. Ibintu bitandukanye, birimo inenge mu mikorere ya fibroblast, ibibazo byo gushinga kolajeni, imikorere y'ubudahangarwa bw'uturemangingo, n'imikorere ya phagocyte, bishobora kubangamira gukira kw'ibikomere ku barwayi ba diyabete. Ubushakashatsi bwinshi bwagaragaje ko uruhu rudafite umwuka mwiza nk'ikintu gikomeye gishobora gutera gucibwa ibice bitewe na DFIs.
Nk'imwe mu mahitamo agezweho yo kuvura DFIByatangajwe ko HBOT yongera cyane igipimo cyo gukira kw'ibisebe by'ibirenge bya diyabete, bityo bikagabanya gukenera gucibwamo ibice no kubagwa bigoranye. Ntabwo bigabanya gusa akamaro ko gukora ibikorwa bisaba ibikoresho byinshi, nko kubaga ibisebe byo mu kibuno no gutera uruhu, ahubwo binatanga ikiguzi gito n'ingaruka nke ugereranije n'uburyo bwo kubaga. Ubushakashatsi bwakozwe na Chen et al. bwagaragaje ko imyitozo irenga 10 ya HBOT yatumye igipimo cyo gukira kw'ibikomere ku barwayi ba diyabete kizamuka ku kigero cya 78.3%.
2. Kwandura indwara zoroshye ziterwa n'imitsi
Indwara zandurira mu ngingo zoroshye (NSTI) akenshi ziba ari nyinshi, akenshi zikomoka ku ruvange rw'udukoko twanduzanya twa bagiteri zikora ku mubiri n'izidafite umwuka kandi akenshi zijyana no gukora imyuka. Nubwo NSTI zidakunze kugaragara, zigaragaza impfu nyinshi bitewe n'uko zigenda ziyongera vuba. Gusuzuma no kuvura vuba kandi bikwiye ni ingenzi kugira ngo haboneke umusaruro mwiza, kandi HBOT yagiriwe inama nk'uburyo bw'inyongera mu kuvura NSTI. Nubwo hakiri impaka ku ikoreshwa rya HBOT muri NSTI bitewe n'uko nta bushakashatsi buhari bwagenzuwe,ibimenyetso bigaragaza ko bishobora kuba bifitanye isano no kwiyongera kw'umubare w'abakira indwara ziterwa n'ibura ry'ingingo zabo ndetse no kubungabunga ingingo zabo mu barwayi ba NSTIInyigo yakozwe nyuma y’aho yagaragaye ko umubare w’impfu mu barwayi ba NSTI bahabwa HBOT wagabanutse cyane.
1.3 Kwandura indwara zo mu gace k'abazwe
SSI zishobora gushyirwa mu byiciro hashingiwe ku gace k’umubiri w’ubwandu kandi zishobora guturuka ku ndwara zitandukanye, harimo na bagiteri zo mu bwoko bwa aerobic na anaerobic. Nubwo habayeho iterambere mu ngamba zo kurwanya ubwandu, nko gukoresha uburyo bwo gufunga, gukoresha imiti yica udukoko, no kunoza imikorere yo kubaga, SSI ziracyari ingorane ihoraho.
Isuzuma rimwe ry’ingenzi ryakozwe ku kamaro ka HBOT mu gukumira SSIs zimbitse mu kubaga indwara ya scoliosis y’imitsi. HBOT mbere yo kubagwa ishobora kugabanya cyane ikwirakwira rya SSIs no koroshya gukira kw’ibikomere. Ubu buryo bwo kuvura budakoresha uburyo butuma habaho ahantu urugero rwa ogisijeni mu bice by’ibikomere rwiyongera, ibyo bikaba byarajyanye no kwica ogisijeni ku ndwara zitera indwara. Byongeye kandi, bukemura ikibazo cyo kugabanuka k’urugero rw’amaraso na ogisijeni bigira uruhare mu iterambere rya SSIs. Uretse izindi ngamba zo kurwanya ubwandu, HBOT yagiriwe inama cyane cyane ku kubaga hakoreshejwe uburyo bwo kuvura indwara zandujwe n’uruhu nk’uburyo bwo kuvura umwijima.
1.4 Gutwika
Ubushye ni imvune ziterwa n'ubushyuhe bukabije, amashanyarazi, imiti cyangwa imirasire kandi bishobora gutera indwara nyinshi n'impfu. HBOT ni ingirakamaro mu kuvura ubushye binyuze mu kongera urugero rwa ogisijeni mu ngingo zangiritse. Mu gihe ubushakashatsi ku nyamaswa n'ubuvuzi butanga ibisubizo bitandukanye ku bijyanyeakamaro ka HBOT mu kuvura ubushye, inyigo yakozwe ku barwayi 125 bahiye yagaragaje ko HBOT nta ngaruka nini yagaragaje ku mubare w'impfu cyangwa umubare w'ababazwe ariko yagabanyije igihe cyo gukira (iminsi 19.7 ugereranije n'iminsi 43.8). Guhuza HBOT n'uburyo bwo gucunga ubushye busesuye bishobora kugenzura neza sepsis ku barwayi bahiye, bigatuma igihe cyo gukira kiba gito kandi amazi agabanye. Ariko, hakenewe ubundi bushakashatsi bwimbitse kugira ngo hemezwe uruhare rwa HBOT mu gucunga ubushye bukabije.
1.5 Osteomyelitis
Osteomyelitis ni indwara ifata amagufwa cyangwa umwongo w'amagufwa ikunze guterwa n'udukoko twa bagiteri. Kuvura osteomyelitis bishobora kugorana bitewe n'uko amaraso adahagije ajya mu magufwa ndetse n'uburyo imiti yica udukoko idashobora kwinjira mu mwongo. Osteomyelitis idakira irangwa n'udukoko tudakira, ububyimbirwe bworoheje, no kurema kw'imitsi y'amagufwa. Osteomyelitis idakira yerekeza ku ndwara zidakira z'amagufwa zikomeza cyangwa zikongera kugaruka nubwo zivurwa neza.
HBOT byagaragaye ko yongera cyane urugero rwa ogisijeni mu magufwa yanduye. Inyigo nyinshi z’ubushakashatsi n’iz’amatsinda y’abantu zigaragaza ko HBOT yongera umusaruro w’ubuvuzi ku barwayi ba osteomyelitis. Bisa nkaho ikora binyuze mu buryo butandukanye, harimo kongera imikorere y’imikorere y’umubiri, gukumira indwara za bagiteri, kongera ingaruka za antibiyotike, kugabanya ububyimbirwe, no gukira.inzira. Nyuma ya HBOT, 60% kugeza 85% by'abarwayi bafite osteomyelitis idakira kandi idakira bagaragaza ibimenyetso byo kugabanuka k'ubwandu.
1.6 Indwara z'ibihumyo
Ku isi yose, abantu barenga miliyoni eshatu barwara indwara z’ibihumyo zidakira cyangwa zikwirakwira, bigatuma abantu barenga 600.000 bapfa buri mwaka. Ingaruka zo kuvura indwara z’ibihumyo zikunze kwangirika bitewe n’ibintu nko guhinduka k’ubudahangarwa bw’umubiri, indwara zisanzwe, n’imiterere y’indwara zitera indwara. HBOT irimo kuba uburyo bwiza bwo kuvura indwara zikomeye z’ibihumyo bitewe n’umutekano wayo no kudakwirakwira kwayo. Ubushakashatsi bwerekana ko HBOT ishobora kugira ingaruka nziza ku ndwara z’ibihumyo nka Aspergillus na Mycobacterium tuberculosis.
HBOT iteza imbere ingaruka mbi zo mu bwoko bwa Aspergillus, aho imikorere yayo yiyongera mu bwoko budafite superoxide dismutase (SOD). Indwara zo mu bwoko bwa hypoxia mu gihe cy’ubwandu bw’ibihumyo zitera imbogamizi mu gutanga imiti irwanya udukoko, bigatuma ubwiyongere bw’umwuka wa ogisijeni uva kuri HBOT bushobora kuba ingirakamaro, nubwo hakenewe ubushakashatsi bw’inyongera.
Imiterere y'imiti ya HBOT irwanya udukoko
Ahantu hakomeye hakozwe na HBOT hatera impinduka mu miterere y’umubiri no mu mikorere ya biokemike bigatuma habaho imiti yica udukoko, bigatuma iba umuti w’inyongera ku ndwara. HBOT igaragaza ingaruka zitangaje ku bagiteri zo mu mwuka zirimo aerobic na bagiteri zidafite umwuka binyuze mu buryo nk’ubukorane buziguye bwa bagiteri, kongera ubushobozi bw’ubudahangarwa bw’umubiri, n’ingaruka zihuriweho n’imiti yihariye irwanya udukoko.
2.1 Ingaruka zitaziguye za HBOT ku mikorobe
Ingaruka za HBOT zo kurwanya udukoko ziterwa ahanini no gukora ubwoko bwa ogisijeni ikora neza (ROS), irimo anions za superoxide, peroxide ya hydrogen, radicals za hydroxyl, na iyons za hydroxyl—byose bivuka mu gihe cy’ihinduka ry’uturemangingo.
Imikoranire hagati ya O₂ n'ibice by'ingirabuzimafatizo ni ingenzi mu gusobanukirwa uburyo ROS ikora mu turemangingo. Mu bihe bimwe na bimwe byitwa oxidative stress, uburinganire hagati yo gukora ROS no kwangirika kwayo burahungabana, bigatera kwiyongera kwa ROS mu turemangingo. Ikorwa rya superoxide (O₂⁻) riterwa imbaraga na superoxide dismutase, nyuma igahindura O₂⁻ mo hydrogen peroxide (H₂O₂). Iri hinduka rirushaho kwiyongera bitewe na Fenton reaction, ikora oxidation ya Fe²⁺ kugira ngo ikore hydroxyl radicals (·OH) na Fe³⁺, bityo bigatangiza urukurikirane rwa redox rwa ROS no kwangirika kwa selile.
Ingaruka z'uburozi bwa ROS zireba ibice by'ingenzi by'uturemangingo nka ADN, RNA, poroteyine, na lipide. Ikigaragara ni uko ADN ari yo ntego y'ibanze y'uburozi buterwa na H₂O₂, kuko ibangamira imiterere ya deoxyribose kandi ikangiza imiterere y'ibanze. Kwangirika kw'umubiri guterwa na ROS kugera ku miterere ya helix ya ADN, bishobora guterwa no gushonga kwa lipide guterwa na ROS. Ibi bigaragaza ingaruka mbi zo kwiyongera kwa ROS muri sisitemu y'ibinyabuzima.
Imikorere ya ROS yo kurwanya mikorobe
ROS igira uruhare runini mu kubuza mikorobe gukura, nk'uko bigaragazwa no gukora ROS iterwa na HBOT. Ingaruka z'uburozi bwa ROS zireba mu buryo butaziguye ibice bigize selile nka ADN, poroteyine, na lipide. Ubwinshi bw'ubwoko bwa ogisijeni bushobora kwangiza lipide mu buryo butaziguye, bigatuma lipide zisohoka. Iyi gahunda ibangamira ubusugire bw'uturemangingo, bityo bigatuma imikorere ya receptor na proteine bifitanye isano na membrane igabanuka.
Byongeye kandi, poroteyine, nazo zikaba ari intego zikomeye za molekile za ROS, zihinduka mu buryo bwihariye mu bisigazwa bitandukanye bya aside amine nka cysteine, methionine, tyrosine, phenylalanine, na tryptophan. Urugero, HBOT byagaragaye ko itera impinduka mu mikorere ya oxidative muri poroteyine nyinshi muri E. coli, harimo na elelongation factor G na DnaK, bityo bigira ingaruka ku mikorere yazo.
Kongera Ubudahangarwa bw'Umubiri Binyuze muri HBOT
Imiterere ya HBOT irwanya ububyimbirwebyanditse, bigaragaza ko ari ingenzi mu kugabanya kwangirika kw'ingingo no kugabanya iterambere ry'ubwandu. HBOT igira ingaruka zikomeye ku mikorere ya cytokine n'ibindi bigenzura ububyimbirwe, bigira ingaruka ku mikorere y'ubudahangarwa bw'umubiri. Sisitemu zitandukanye z'igerageza zabonye impinduka zitandukanye mu mikorere ya za gene no gukora poroteyine nyuma ya HBOT, ibyo bikaba byongera cyangwa bigagabanya ibintu bikura na cytokine.
Mu gihe cya HBOT, kwiyongera k'urugero rwa O₂ bitera ingaruka zitandukanye ku turemangingo, nko kugabanya irekurwa ry'ibintu bitera ububyimbirwe no guteza imbere apoptosis ya lymphocyte na neutrophil. Muri rusange, ibi bikorwa byongera uburyo bwo kurwanya mikorobe mu mubiri, bityo bigafasha gukira indwara zandura.
Byongeye kandi, ubushakashatsi bwerekana ko kwiyongera k'urugero rwa O₂ mu gihe cya HBOT bishobora kugabanya igaragara rya cytokines zitera ububyimbirwe, harimo interferon-gamma (IFN-γ), interleukin-1 (IL-1), na interleukin-6 (IL-6). Izi mpinduka zirimo kandi kugabanya igipimo cya CD4:CD8 T cells no guhindura izindi receptors zishongesha, amaherezo bikazamura urugero rwa interleukin-10 (IL-10), ibi bikaba ari ingenzi mu kurwanya ububyimbirwe no gutuma gukira.
Imikorere ya HBOT yo kurwanya udukoko ifitanye isano n'uburyo bugoye bw'ibinyabuzima. Superoxide n'umuvuduko mwinshi byavuzwe ko bitera imbaraga mu buryo budasanzwe ibikorwa bya HBOT birwanya udukoko ndetse no kugabanuka kwa neutrophil. Nyuma ya HBOT, kwiyongera cyane kwa ogisijeni byongera ubushobozi bwa neutrophil bwo kwica bagiteri, igice cy'ingenzi cy'ubwirinzi bw'umubiri. Byongeye kandi, HBOT igabanya kwifata kwa neutrophil, bituruka ku mikoranire ya β-integrins kuri neutrophils hamwe na molekile zifatana hagati y'uturemangingo (ICAM) ku turemangingo tw'inyuma. HBOT ibuza imikorere ya neutrophil β-2 integrin (Mac-1, CD11b/CD18) binyuze mu nzira iterwa na nitric oxide (NO), bigatuma neutrophils yimuka aho yanduriye.
Guhindura neza urugingo rwa cytoskeleton ni ngombwa kugira ngo neutrophils zikore neza mu kugabanya indwara. Byagaragaye ko S-nitrosylation ya actin itera imbaraga mu kugabanya actin polymerization, ishobora koroshya imikorere ya phagocytic ya neutrophils nyuma yo kuvurwa na HBOT mbere yo kuvurwa. Byongeye kandi, HBOT itera apoptosis mu miterere y’uturemangingo twa T tw’abantu binyuze mu nzira za mitochondrial, hamwe n’urupfu rwihuta rwa lymphocyte nyuma ya HBOT ruvugwa. Kubuza caspase-9—nta ngaruka kuri caspase-8—byagaragaje ingaruka za HBOT ku budahangarwa bw’umubiri.
Ingaruka za HBOT zishingiye ku mikorobe
Mu ikoreshwa ry’ubuvuzi, HBOT ikunze gukoreshwa hamwe na antibiyotike kugira ngo irwanye indwara neza. Imiterere ya hyperoxide igerwaho muri HBOT ishobora kugira ingaruka ku mikorere y’imiti imwe n’imwe ya antibiyotike. Ubushakashatsi bwerekana ko imiti yihariye yica bagiteri, nka β-lactams, fluoroquinolones, na aminoglycosides, idakora gusa binyuze mu buryo busanzwe ahubwo inashingira ku gice cy’imikorere ya bagiteri. Kubwibyo, kuba hari ogisijeni n’imiterere y’imikorere ya bagiteri ni ingenzi cyane mu gusuzuma ingaruka za antibiyotike ku kuvura.
Ibimenyetso bikomeye byagaragaje ko urugero ruto rwa ogisijeni rushobora kongera ubudahangarwa bwa Pseudomonas aeruginosa kuri piperacillin/tazobactam kandi ko ikirere gifite ogisijeni nke nacyo bigira uruhare mu kongera ubudahangarwa bwa Enterobacter cloacae kuri azithromycin. Ku rundi ruhande, hari indwara zimwe na zimwe ziterwa na ogisijeni zishobora kongera ubushobozi bwa bagiteri bwo kwandura antibiyotike za tetracycline. HBOT ikora nk'uburyo bwiza bwo kuvura binyuze mu gutuma habaho metabolisme ya aerobic no kongera ogisijeni mu ngingo zanduye, bityo bigatuma indwara ziterwa na ogisijeni zirushaho kwandura antibiyotike.
Mu bushakashatsi bwakozwe mbere yo kuvura, HBOT—itangwa kabiri ku munsi mu masaha 8 kuri 280 kPa—hamwe na tobramycin (20 mg/kg/umunsi) byagabanyije cyane umubare wa bagiteri muri Staphylococcus aureus infectious endocarditis. Ibi bigaragaza ubushobozi bwa HBOT nk'ubuvuzi bw'inyongera. Ubushakashatsi bwakozwe bwagaragaje ko munsi ya 37°C n'umuvuduko wa 3 ATA mu masaha 5, HBOT yongereye cyane ingaruka za imipenem ku ndwara ya Pseudomonas aeruginosa yanduye macrophage. Byongeye kandi, uburyo HBOT yahujwe na cephazolin byagaragaye ko ari ingirakamaro cyane mu kuvura Staphylococcus aureus osteomyelitis mu nyamaswa ugereranije na cephazolin yonyine.
HBOT yongera cyane uburyo ciprofloxacin yica bagiteri kuri Pseudomonas aeruginosa biofilms, cyane cyane nyuma y'iminota 90 yo kwibasirwa n'iyi ndwara. Uku kwiyongera kw'iyi ndwara guterwa no kurema ubwoko bwa ogisijeni bukora neza (ROS) kandi bigaragaza ubushobozi bwo kwihuta mu bintu bifite peroxidase-defective mutants.
Mu buryo bw'indwara ya pleurite iterwa na Staphylococcus aureus (MRSA) idashobora guterwa na methicillin, ingaruka ku bufatanye bwa vancomycin, teicoplanin, na linezolid hamwe na HBOT zagaragaje ko MRSA yarushijeho kugira akamaro. Metronidazole, umuti urwanya udukoko ukoreshwa cyane mu kuvura indwara zikomeye ziterwa n'umwuka mubi n'udukoko twinshi nka diyabete (DFIs) n'indwara ziterwa n'aho umuntu abagwa (SSIs), yagaragaje ubushobozi bwo kurwanya udukoko twinshi mu gihe umuntu adakora. Ubushakashatsi bw'ejo hazaza bugomba gukorwa kugira ngo hasuzumwe ingaruka ziterwa na HBOT hamwe na metronidazole haba mu mubiri cyangwa mu mubiri.
Uburyo HBOT Irwanya Mikorobe Ishobora Kurwanya Bagiteri Zidakira
Bitewe n’impinduka n’ikwirakwira ry’imiti irwanya indwara, imiti gakondo igabanya ubukana bwayo ikunze gutakaza imbaraga zayo uko igihe kigenda gihita. Byongeye kandi, HBOT ishobora kuba ingenzi mu kuvura no gukumira indwara ziterwa n’udukoko turwanya indwara nyinshi, ikaba ari ingamba y’ingenzi iyo imiti irwanya indwara idakira. Ubushakashatsi bwinshi bwagaragaje ingaruka zikomeye za HBOT ku mikorobe zirwanya indwara ziterwa n’indwara. Urugero, isuzuma rya HBOT ry’iminota 90 kuri 2 ATM ryagabanyije cyane ukwiyongera kwa MRSA. Byongeye kandi, mu buryo bw’ikigereranyo, HBOT yongereye ingaruka za antibiyotike zitandukanye ku ndwara za MRSA. Raporo zemeje ko HBOT ifite akamaro mu kuvura osteomyelitis iterwa na Klebsiella pneumoniae ikora OXA-48 idasaba antibiyotike iyo ari yo yose y’inyongera.
Muri make, ubuvuzi bwa ogisijeni ikabije bugaragaza uburyo butandukanye bwo kurwanya ubwandu, bukongera ubushobozi bw'ubudahangarwa bw'umubiri mu gihe bunatuma imiti irwanya udukoko ikoreshwa mu kurwanya udukoko irushaho kuba myiza. Hamwe n'ubushakashatsi n'iterambere birambuye, bufite ubushobozi bwo kugabanya ingaruka zo kudakira imiti irwanya udukoko, butanga icyizere mu rugamba rwo kurwanya indwara za bagiteri.
Igihe cyo kohereza: Gashyantare-28-2025